Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

Author:

Burke Christopher1,Jankute Monika1,Moynihan Patrick1,Gonzalez del Rio Ruben2,Li Xiaojun3,Esquivias Jorge2,Lelièvre Joël2,Cox Jonathan A. G.4,Sacchettini James3,Besra Gurdyal S.1

Affiliation:

1. Institute of Microbiology and Infection School of Biosciences University of Birmingham Birmingham UK

2. Diseases of the Developing World GlaxoSmithKlineTres Cantos Madrid Spain

3. Department of Biochemistry and Biophysics Texas A&M University College Station Texas United States

4. School of Life & Health Sciences Aston University Birmingham UK

Publisher

Wiley

Reference36 articles.

1. World Health Organisation.Global Tuberculosis Report 2017.http://apps.who.int/iris/bitstream/handle/10665/259366/9789241565516‐eng.pdf?sequence=1 (2017) doi:WHO/HTM/TB/2017.23.

2. World Health Organization.MDR TB/RR TB Factsheet TB 2017. in World Health Organization 1–2 (2017).

3. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

4. The specific inhibition of the DNA-directed RNA synthesis by rifamycin

5. INHIBITION OF DNA-DEPENDENT RNA SYNTHESIS BY RIFAMYCINS

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