DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma-Reference-Cited by-同舟云学术

DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

Published:2019-12 Issue:12 Volume:33 Page:14270-14280
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:The FASEB Journal

Author:

Barbosa da Cruz Dayana¹,Helms Julie²³,Aquino Lluvia Ramírez¹,Stiel Laure²⁴,Cougourdan Lucas¹,Broussard Cedric⁵⁶,Chafey Philippe⁵⁶,Riès-Kautt Madeleine⁵⁶,Meziani Ferhat²⁴,Toti Florence⁴,Gaussem Pascale¹⁷,Anglés-Cano Eduardo¹

Affiliation:

1. Innovative Therapies in Haemostasis, INSERM Unité Mixte de Recherche (UMR)_S 1140, Université de Paris, Paris, France;

2. Service de Médecine Intensive–Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France;

3. ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg, Strasbourg, France;

4. Regenerative Nanomedicine, INSERM UMR_S 1260, Université de Strasbourg, Strasbourg, France;

5. Plateforme Protéomique 3P5, Université de Paris, Paris, France;

6. Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Université de Paris, Paris, France;

7. Assistance Publique–Hôpitaux de Paris, Service d’Hématologie Biologique, Hôpital Européen Georges Pompidou, Paris, France

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference65 articles.

1. Basic mechanisms and regulation of fibrinolysis

2. Crystal structure of the native plasminogen reveals an activation-resistant compact conformation

3. Characterization of the binding of plasminogen to fibrin surfaces: The role of carboxy-terminal lysines