Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei

Author:

Balogun Emmanuel Oluwadare12,Inaoka Daniel Ken123,Shiba Tomoo4,Tsuge Chiaki2,May Benjamin4,Sato Tomohiro5,Kido Yasutoshi16,Nara Takeshi7,Aoki Takashi7,Honma Teruki8,Tanaka Akiko8,Inoue Masayuki9,Matsuoka Shigeru9,Michels Paul A. M.1011,Watanabe Yoh‐Ichi2,Moore Anthony L.4,Harada Shigeharu5,Kita Kiyoshi2123

Affiliation:

1. Department of BiochemistryAhmadu Bello UniversityZariaNigeria

2. Department of Biomedical ChemistryGraduate School of Medicine

3. Department of Molecular Infection Dynamics, Shionogi Global Infectious Disease DivisionInstitute of Tropical Medicine (NEKKEN), Nagasaki UniversityNagasakiJapan

4. Biochemistry and MedicineSchool of Life Sciences, University of SussexBrightonUnited Kingdom

5. Department of Applied BiologyGraduate School of Science and Technology, Kyoto Institute of TechnologyKyotoJapan

6. Department of ParasitologyGraduate School of Medicine, Osaka City UniversityOsakaJapan

7. Department of Molecular and Cellular ParasitologyJuntendo University School of MedicineTokyoJapan

8. Systems and Structural Biology CenterRikenYokohamaJapan

9. Graduate School of Pharmaceutical Sciences, The University of TokyoTokyoJapan

10. Centre for Immunity, Infection, and Evolution

11. Centre for Translational and Chemical BiologySchool of Biological Sciences, University of EdinburghEdinburghUnited Kingdom

12. School of Tropical Medicine and Global Health

Funder

Government of the United Kingdom

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference53 articles.

1. World Health Organization. (2016)Trypanosomiasis human African (sleeping sickness). Accessed May 26 2019 at:https://www.who.int/trypanosomiasis_african/en/

2. Complete In Vitro Life Cycle of Trypanosoma congolense: Development of Genetic Tools

3. Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes

4. Estimating and Mapping the Population at Risk of Sleeping Sickness

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