RPGRIP1L as a new biomarker for prognosis and tumor immune of breast cancer

Author:

Yi Jianing1ORCID,Liu Luyao1ORCID,Chen Yongzhi2ORCID,Ding Tianjinhao1ORCID,Fan Peizhi1ORCID,Yu Jie1ORCID,Zeng Jie1ORCID

Affiliation:

1. Department of Breast and Thyroid Gland Surgery, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha Hunan China

2. Department of Hepatobiliary Surgery, Clinical Medical College Yangzhou University Yangzhou Jiangsu China

Abstract

AbstractThe Retinitis pigmentosa GTPase regulator interacting protein 1‐like (RPGRIP1L) gene encodes an important protein that performs various physiological functions. Variants of RPGRIP1L are related to a number of diseases. However, it is currently unknown whether RPGRIP1L is correlated with breast invasive carcinoma (BRCA). In BRCA tissue specimens, the expression of RPGRIP1L was found to be elevated in comparison to its levels in normal breast tissue. A notable decline in survival rates was associated with patients exhibiting heightened RPGRIP1L gene expression. Consistent with these findings, our data also show the above results. Furthermore, elevated expression of RPGRIP1L corresponded with a spectrum of unfavorable clinicopathological features, including the presence of human epidermal growth factor receptor 2 (HER2) positive, estrogen receptor (ER) positive, over 60 years old, T2, N0, and N3. At the same time, our research indicated that 50 genes and 15 proteins were positively related to RPGRIP1L, and that these proteins and genes were mostly involved in T cell proliferation, immune response, cytokine activity, and metabolic regulation. In addition, in the present study, there was a significant correlation between RPGRIP1L expression and immune cell infiltration. Finally, we found that four Chemicals could downregulate the expression of RPGRIP1L. Altogether, our results strongly indicated that RPGRIP1L might serve as a new prognostic biomarker for BRCA.

Publisher

Wiley

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