Affiliation:
1. Biological Function of Food Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Olsztyn Poland
2. Department of Animal Nutrition and Feed Science University of Warmia and Mazury in Olsztyn Olsztyn Poland
Abstract
AbstractIntradermal adipocytes form dermal white adipose tissue (dWAT), a unique fat depot localized in the lower layer of the dermis. However, recognition of molecular factors regulating dWAT development, homeostasis, and bioactivity is limited. Using Foxn1−/− and Foxn1+/+ mice, we demonstrated that epidermally expressed Foxn1 regulates dWAT development and defines the adipogenic capacity of dermal fibroblasts. In intact and post‐wounded skin, Foxn1 contributes to the initial stimulation of dWAT adipogenesis and participates in the modulation of lipid metabolism processes. Furthermore, Foxn1 activity strengthens adipogenic processes through Bmp2 and Igf2 signaling and regulates lipid metabolism in differentiated dermal fibroblasts. The results reveal the contribution of Foxn1 to dWAT metabolism, thus identifying possible targets for modulation and regulation of dWAT in physiological and pathological processes in the skin.
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology