TRIM26 restricts Epstein–Barr virus infection in nasopharyngeal epithelial cells through K48‐linked ubiquitination of HSP‐90β

Author:

Zhang Mingjiao123,Tan Haiqi23,Gong Yibing23,Faleti Oluwasijibomi Damola234,Li Dengke5,Yang Jinlong23,Huang Jing23,Long Jingyi23,Luo Qingshuang23,Wu Gongfa6,Zheng Lei1,Lyu Xiaoming23ORCID

Affiliation:

1. Department of Laboratory Medicine Nanfang Hospital, Southern Medical University Guangzhou China

2. Department of Laboratory Medicine The Third Affiliated Hospital, Southern Medical University Guangzhou China

3. The Third School of Clinical Medicine Southern Medical University Guangzhou China

4. Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong China

5. Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences Southern Medical University Guangzhou China

6. Department of pathology The Fourth Affiliated Hospital of Guangzhou Medical University Guangzhou China

Abstract

AbstractThe tripartite interaction motif (TRIM) family of proteins is known for their antiviral activity through different mechanisms, such as interfering with viral components, regulating immune responses, and participating in autophagy‐mediated defense pathways. In this study, we investigated the role of tripartite interaction motif 26 (TRIM26), which is encoded by a major histocompatibility complex (MHC) gene, in regulating Epstein–Barr virus (EBV) infection of nasopharyngeal epithelial cells. We found that TRIM26 expression was induced upon EBV infection and that it indirectly targeted EphA2, a crucial epithelial receptor for EBV entry. Our results showed that TRIM26 interacted with heat shock protein 90‐beta (HSP‐90β) and promoted its polyubiquitination, which led to its degradation via the proteasome pathway. This, in turn, affected EphA2 integrity and suppressed EBV infection. These findings suggest that TRIM26 could be a valuable target for developing therapeutic interventions against EBV infection and its associated pathogenesis.

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism;International Journal of Molecular Sciences;2024-04-23

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3