Infectious hepatitis E virus excreted into the vagina

Author:

Cong Chao1ORCID,Xia Yueping1ORCID,Gong Shilin1ORCID,Li Tengyuan1ORCID,Liu Huichan1ORCID,Zhong Guo1ORCID,Chen Dongxue1ORCID,Zhao Wanqiu1ORCID,Yu Wenhai2ORCID,Yao Yinjie3ORCID,Liu Jiankun4ORCID,Wei Daqiao1ORCID,Cao Hongcui5ORCID,Huang Fen15ORCID

Affiliation:

1. School of Medicine, The Academy for Cells and Life Health, Faculty of Life Science and Technology Kunming University of Science and Technology Kunming PR China

2. Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming PR China

3. Kunming City Maternal and Child Health Hospital Kunming PR China

4. 920th Hospital of the PLA Joint Logistics Support Force Kunming PR China

5. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou PR China

Abstract

AbstractHepatitis E virus (HEV) persists in the male genital tract that associates with infertility. However, the presence of HEV in the female genital tract is unreported. Vaginal secretions, cervical smears, and cervix uteri were collected to explore the presence of HEV in the female genital tract. HEV RNA and/or antigens were detected in the vaginal secretions, cervical smears, and the cervix uteri of women. The infectivity of HEV excreted into vaginal secretions was further validated in vitro. In addition, HEV replicates in the female genital tract were identified in HEV‐infected animal models by vaginal injection or vaginal mucosal infection to imitate sexual transmission. Serious genital tract damage and inflammatory responses with significantly elevated mucosal innate immunity were observed in women or animals with HEV vaginal infection. Results demonstrated HEV replicates in the female genital tract and causes serious histopathological damage and inflammatory responses.

Funder

National Natural Science Foundation of China

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Natural Science Foundation of Yunnan Province

Publisher

Wiley

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