Affiliation:
1. Zhejiang University School of Medicine Zhejiang Hangzhou China
2. The Affiliated Hospital of Stomatology, School of Stomatology Zhejiang University School of Medicine Zhejiang Hangzhou China
3. The Affiliated Hospital of Stomatology, School of Stomatology Zhejiang University School of Medicine and Key Laboratory of Oral Biomedical Research of Zhejiang Province Zhejiang Hangzhou China
Abstract
AbstractOsteoarthritis (OA) and rheumatoid arthritis (RA) are two common forms of arthritis with undefined etiology and pathogenesis. Yes‐associated protein (YAP) and its homolog transcriptional coactivator with PDZ‐binding motif (TAZ), which act as sensors for cellular mechanical and inflammatory cues, have been identified as crucial players in the regulation of joint homeostasis. Current studies also reveal a significant association between YAP/TAZ and the pathogenesis of OA and RA. The objective of this review is to elucidate the impact of YAP/TAZ on different joint tissues and to provide inspiration for further studying the potential therapeutic implications of YAP/TAZ on arthritis. Databases, such as PubMed, Cochran Library, and Embase, were searched for all available studies during the past two decades, with keywords “YAP,” “TAZ,” “OA,” and “RA.”
Funder
National Natural Science Foundation of China