Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

Author:

Erber Ralf1,Thurnher Andreas1,D. Katsen Alice2,Groth Gesine3,Kerger Heinz3,Hammes Hans‐Peter4,D. Menger Michael2,Ullrich Axel5,Vajkoczy Peter1

Affiliation:

1. Department of Neurosurgery Medical Faculty of the University of Heidelberg MannheimGermany

2. Institute for Clinical and Experimental Surgery University of Saarland Homburg/Saar Germany

3. Department of Anesthesiology and Intensive Care Medicine MannheimGermany

4. Vth Medicine Clinic Medical Faculty of the University of Heidelberg MannheimGermany

5. Department of Molecular Biology Max‐Planck‐Institute for Biochemistry Martinsried Germany

Funder

European Commission

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference54 articles.

1. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

2. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors;Prewett M.;Cancer Res.,1999

3. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk‐1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types;Fong T. A.;Cancer Res.,1999

4. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model;Drevs J.;Cancer Res.,2000

5. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

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