Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage

Author:

Daryadel Arezoo1,Ruiz Pedro A.2,Gehring Nicole1,Stojanovic Dragana1,Ugrica Marko1,Bettoni Carla1,Sabrautzki Sibylle3,Pastor‐Arroyo Eva‐Maria1,Frey‐Wagner Isabelle2,Lorenz‐Depiereux Bettina4,Strom Tim M.5,Angelis Martin Hrabě367,Rogler Gerhard2,Wagner Carsten A.1ORCID,Rubio‐Aliaga Isabel1ORCID

Affiliation:

1. Institute of Physiology University of Zurich (UZH), and National Center of Competence in Research NCCR Kidney.CH Zurich Switzerland

2. Department of Gastroenterology and Hepatology University Hospital of Zurich, University of Zurich Zurich Switzerland

3. Institute of Experimental Genetics German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH) Neuherberg85764Germany

4. Institute of Human Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg Germany

5. Institut für Humangenetik Klinikum rechts der Isar der Technischen Universität München München Germany

6. Lehrstuhl für Experimentelle Genetik Technische Universität München Freising‐Weihenstephan Germany

7. Member of German Center for Diabetes Research (DZD) Neuherberg Germany

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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