Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition

Author:

Smith‐Cortinez Natalia1,Fagundes Raphael R.1,Gomez Valentina2,Kong Defu1,Waart Dirk R.2,Heegsma Janette1,Sydor Svenja3,Olinga Peter4,Meijer Vincent E.5,Taylor Cormac T.6,Bank Ruud7,Paulusma Coen C.2,Faber Klaas Nico1

Affiliation:

1. Department of Hepatology and Gastroenterology University Medical Center Groningen University of Groningen Groningen the Netherlands

2. Tytgat Institute for Liver and Intestinal Research Amsterdam Gastroenterology and Metabolism Amsterdam UMC University of Amsterdam Amsterdam the Netherlands

3. Department of Internal Medicine University Hospital Knappschaftskrankenhaus Ruhr‐University Bochum Bochum Germany

4. Department of Pharmaceutical Technology and Biopharmacy University of Groningen Groningen the Netherlands

5. Department of Surgery Division of Hepato‐Pancreato‐Biliary Surgery and Liver Transplantation University Medical Center Groningen University of Groningen Groningen the Netherlands

6. School of Medicine and Medical Science and the Conway Institute University College Dublin Dublin Ireland

7. Department of Pathology and Medical Biology University Medical Center Groningen University of Groningen Groningen the Netherlands

Funder

Comisión Nacional de Investigación Científica y Tecnológica

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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