Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

Author:

Weber Minéia1,Mera Paula12,Casas Josefina34,Salvador Javier25,Rodríguez Amaia26,Alonso Sergio7,Sebastián David89,Soler‐Vázquez M. Carmen1,Montironi Carla1011,Recalde Sandra1,Fucho Raquel1,Calderón‐Domínguez María1,Mir Joan Francesc1,Bartrons Ramon12,Escola‐Gil Joan Carles913,Sánchez‐Infantes David214,Zorzano Antonio89,Llorente‐Cortes Vicenta151617,Casals Núria218,Valentí Víctor619,Frühbeck Gema26,Herrero Laura12,Serra Dolors12

Affiliation:

1. Department of Biochemistry and Physiology School of Pharmacy and Food Sciences Institut de Biomedicina de la Universitat de Barcelona (IBUB)Universitat de Barcelona Barcelona Spain

2. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain

3. Research Unit on BioActive Molecules Department of Biological Chemistry Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC Barcelona Spain

4. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III Madrid Spain

5. Department of Endocrinology & Nutrition Clínica Universidad de Navarra Pamplona Spain

6. Metabolic Research Laboratory Clínica Universidad de NavarraIdiSNA Pamplona Spain

7. Cancer Genetics and Epigenetics Group, Program of Predictive and Personalized Medicine of Cancer Germans Trias i Pujol Research Institute (IGTP‐PMPPC)Campus Can Ruti Barcelona Spain

8. Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science and Technology Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia Universitat de Barcelona Barcelona Spain

9. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Instituto de Salud Carlos III Madrid Spain

10. Pathology Department Hospital Clinic de Barcelona Barcelona Spain

11. Liver Cancer Translational Research Laboratory, Liver Unit IDIBAPS‐Hospital ClínicUniversitat de Barcelona Barcelona Spain

12. Departament de Ciències Fisiològiques Facultat de Medicina i Ciències de la SalutUniversitat de Barcelona Spain

13. IIB Sant Pau Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona Spain

14. Germans Trias i Pujol Research Institute (IGTP‐PMPPC)Campus Can Ruti Barcelona Spain

15. Institute of Biomedical Research of Barcelona (IIBB) Spanish National Research Council (CSIC)Biomedical Research Institute Sant Pau (IIB Sant Pau) Barcelona Spain

16. CIBERCVInstitute of Health Carlos III Madrid Spain

17. Cardiovascular Research CenterCSIC‐ICCC Barcelona Spain

18. Basic Sciences Department Faculty of Medicine and Health Sciences Universitat Internacional de Catalunya Sant Cugat del Vallès Spain

19. Department of Surgery Clínica Universidad de Navarra Pamplona Spain

Funder

Ministerio de Economía y Competitividad

European Regional Development Fund

Generalitat de Catalunya

Instituto de Salud Carlos III

Fundació la Marató de TV3

European Foundation for the Study of Diabetes

Eli Lilly and Company

United Nations Educational, Scientific and Cultural Organization

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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