A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone-Reference-Cited by-同舟云学术

A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone

Published:2020-04-29 Issue:6 Volume:34 Page:7234-7246
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Chen Ci‐Di¹,Rudy Melissa A.¹,Zeldich Ella¹,Abraham Carmela R.¹

Affiliation:

1. Klogene Therapeutics, Inc Boston MA USA

Funder

National Institute on Aging

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202000171R

Reference52 articles.

1. Mutation of the mouse klotho gene leads to a syndrome resembling ageing

2. Suppression of Aging in Mice by the Hormone Klotho

3. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice

4. Klotho is a substrate for α-, β- and γ-secretase

5. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets;Drug Discovery Today;2024-09

2. Oncology: Way Forward from Clinical and Molecular Diagnosis to Treatment;Oncology: Genomics, Precision Medicine and Therapeutic Targets;2023

3. The role of α-klotho in human cancer: molecular and clinical aspects;Oncogene;2022-08-29

4. Role of micronutrients in Alzheimer's disease: Review of available evidence;World Journal of Clinical Cases;2022-08-06

5. Klotho and aging phenotypes;Fibroblast Growth Factor 23;2021