The Quantitative Determination of Etonium by the Enzymatic Kinetic-Spectrophotometric Method-Reference-Cited by-同舟云学术

The Quantitative Determination of Etonium by the Enzymatic Kinetic-Spectrophotometric Method

Published:2024-06-19 Issue:1 Volume:22 Page:57-62
ISSN:2518-1548
Container-title:Journal of Organic and Pharmaceutical Chemistry
language:
Short-container-title:J. Org. Pharm. Chem.

Author:

Blazheyevskiy Mykola Ye.¹^ORCID,Kovalska Olena V.¹^ORCID

Affiliation:

1. National University of Pharmacy of the Ministry of Health of Ukraine

Abstract

The use of the cholinesterase enzyme as a component of the analytical system has made it possible to develop a new kinetic-spectrophotometric method, which is alternative to the pharmacopoeial method, for determining the quaternary ammonium salt – ethonium in the substance and a dosage form. This method is characterized by high sensitivity and specificity, and is relatively cheap. The relative standard deviation of the procedure does not exceed 2.7 %, and the limit of quantification is 17 ng mL–1.

Publisher

National University of Pharmacy

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