Age features of the influence of ATP-LONG and molsidomine on heart and vascular contractions

Abstract

The high incidence of cardiovascular discases, the long course and severity of diseases in the elderly and old patients determine the need to use effective and safe drugs for their treatment. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism and energy metabolism of cardiomyocytes, improve vascular tone and blood supply to the myocardium, increase its contractile function. The effect of a combination of ATP-long and molsidomine on vascular and myocardial contractility in young and old rats was studied in in vitro experiments. In experiments on isolated segments of the thoracic aorta, it was found that combination of ATP-long and molsidomine has a vasodilating effect, which did not differ significantly from the action of acetylcholine in animals of both ages. Combined use of ATP-long and molsidomine did not significantly affect the contractility of the isolated heart of young rats under different perfusion regimens. In old rats, the use of a combination of ATP-long and molsidomine had a positive effect on the contractile function of the myocardium under the influence of damaging factors: prevented a decrease in left ventricular pressure during hypoxia and accelerated its growth during reperfusion. The results of the studies indicate a positive effect of the combination of ATP-long and molsidomine on the contractility of blood vessels and myocardium in older animals.