Development of ‘Bondarmine’ disinfectant formulation and study of its Tuberculosis effect

Abstract

The article presents the results of studying the bactericidal properties of the disinfectant ‘Bondarmin’, consisting of potassium peroxymonosulfate, sulfonol (surfactant), adipic acid (hexanedioic acid), and sodium chloride. The active component of the preparation is potassium peroxymonosulfate (KHSO5), which being HSO5 ion in solution, has an oxidizing effect on the cysteine moieties of microorganism proteins. The highest oxidation-reduction potential is achieved in an acidic medium (pH 2.0–2.3), which is provided by a buffer additive — adipic acid, as well as additionally the presence of sodium chloride in the solution, which creates a high ionic force of the solution, and therefore contributes to the high osmotic pressure of the solution — important factors of biocidal action. KHSO5 slowly oxidizes chlorides to chlorine, which has an additional bactericidal effect (high availability of disinfectant to internal surfaces). Studies on the bactericidal properties of the ‘Bondarmin’ disinfectant were carried out in accordance with the methodological recommendations ‘Determination of bactericidal properties of disinfectants, disinfection and control of its quality in tuberculosis of farm animals’. Experimental studies have established bactericidal effect of disinfectant ‘Bondarmin’ in concentration 1.0% per exposure of 3 hr in relation to atypical mycobacteria M. fortuitum and tuberculosis pathogens M. bovis and M. avium