Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents

Abstract

In this work, a racemization method of (S)-1-phenylethanol by niobium salts was developed. Among the salts available, the niobium phosphate hydrate (NbOPO4.nH2O) reduced the enantiomeric excess (ee) of the chiral alcohol from 95 to 0% after 24 h at 60 ºC in toluene. This new racemization agent was combined with a lipase (CALB) in order to achieve a chemoenzymatic dynamic kinetic resolution (DKR). Experiments demonstrated that the DKR process is feasible and the corresponding (R)-1-phenylethyl acetate was obtained with 92% conversion and 85% ee.