Contribution of intestinal transporters to drug absorption and the implications for drug discovery and development (2) : efflux transporters
Author:
Affiliation:
1. Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
2. Drug Metabolism & Physicochemistry Research Laboratory, R&D Division, Daiichi Pharmaceutical Co., Ltd.
Publisher
Japan Society of Drug Delivery System
Subject
Pharmaceutical Science
Link
https://www.jstage.jst.go.jp/article/dds/21/2/21_2_142/_pdf
Reference46 articles.
1. 1) Yamagata T, Morishita M : Oral drug delivery system besed on controlling intestinal transporter function. Drug Delivery System 21 : 119-125, 2006.
2. 2) Sakaeda T, Okamura N, Nagata S, Yagami T, Horinouchi M et al. : Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans. Biol Pharm Bull 24 : 935-940, 2001.
3. 3) Toyobuku H, Tamai I, Ueno K, Tsuji A : Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug. J Pharm Sci 92 : 2249-2259, 2003.
4. 4) Chiou WL, Chung SM, Wu TC, Ma C : A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans. Int J Clin Pharmacol Ther 39 : 93-101, 2001.
5. 5) Lin JH : How significant is the role of P-glycoprotein in drug absorption and brain uptake? Drugs Today 40 : 5-22, 2004.
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1. Drug delivery system based on transport characteristics of biological membranes Oral drug delivery system based on controlling intestinal transporter function;Drug Delivery System;2006
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