Phase III Trials of Eribulin Mesylate (E7389) in Extensively Pretreated Patients With Locally Recurrent or Metastatic Breast Cancer

Author:

Twelves Chris,Cortes Javier,Vahdat Linda T.,Wanders Jantien,Akerele Corina,Kaufman Peter A.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference14 articles.

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2. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B;Hamel;Pharmacol Ther,1992

3. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B;Towle;Cancer Res,2001

4. Discovery of E7389, a fully synthetic macrocyclic ketone analog of halichondrin B;Yu,2005

5. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth;Jordan;Mol Cancer Ther,2005

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