Gabapentin as Adjunctive Therapy in Neonatal Opioid Withdrawal Syndrome: A Case Series

Author:

Patz Caroline1,Liviskie Caren1,Bird Merielle23,Zeller Brandy1,Vesoulis Zachary A.4,Smyser Christopher D.235,McPherson Christopher14

Affiliation:

1. Department of Pharmacy (CP, CL, BZ, CM), St. Louis Children’s Hospital, St. Louis, MO

2. Department of Neurology (MB, CDS), Washington University School of Medicine, St. Louis, MO

3. Department of Pediatrics (MB, CDS), Washington University School of Medicine, St. Louis, MO

4. Division of Newborn Medicine (ZAV, CM), Washington University School of Medicine, St. Louis, MO

5. Department of Radiology (CDS), Washington University School of Medicine, St. Louis, MO

Abstract

OBJECTIVE We describe a single center experience with gabapentin as adjunctive therapy in infants with neonatal opioid withdrawal syndrome (NOWS). METHODS We performed a retrospective chart review of infants receiving gabapentin for NOWS. Data points collected included patient’s sex, gestational age, maternal opioid exposure, NOWS medication dosing and length of therapy, number of failed wean attempts, time to successful morphine wean and duration of morphine wean, length of stay in the neonatal intensive care unit (NICU), and NOWS medications at discharge. RESULTS Six infants received gabapentin as adjunctive treatment for NOWS. All infants failed 2–4 morphine weans before initiation of gabapentin despite the addition of clonidine. All infants that received gabapentin were successfully weaned off morphine. The time to wean off morphine after gabapentin initiation varied from 4–35 days. Maximum gabapentin doses ranged from 15 – 42.7 mg/kg/day. Five infants were discharged from the NICU on gabapentin. CONCLUSIONS Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.

Publisher

Pediatric Pharmacy Advocacy Group

Subject

Pharmacology (medical),Pediatrics, Perinatology and Child Health

Reference15 articles.

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2. Neonatal abstinence syndrome and maternal opioid-related diagnoses in the US, 2010–2017;Hirai;JAMA,2021

3. Neonatal abstinence syndrome among newborn hospitalizations;Department of Health and Human Services Agency for Healthcare Research and Quality Healthcare Cost & Utilization Project,2018

4. Incidence and Costs of Neonatal Abstinence Syndrome Among Infants With Medicaid: 2004–2014;Winkelman;Pediatrics,2018

5. Neonatal Opioid Withdrawal Syndrome;Patrick;Pediatrics,2020

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