Dynamics of Matrix Metalloproteinases in the Oral Environment

Abstract

ABSTRACT Matrix metalloproteinases (MMPs) are an important family of zincdependent endopeptidases that mediate the extracellular matrix (ECM) degradation. The major component of the extracellular matrix, collagen, is catabolized. These enzymes have been implicated in oral pathologic processes, such as periodontal tissue destruction, root caries, tumor invasion, and temporomandibular joint disorders. The aim of this paper was to review of some general aspects of matrix metalloproteinases and discuss the role of these enzymes in normal physiology and pathology with emphasis on the oral environment. This process is important in a number of aspects of dentistry since matrix is constantly turning over. Although the members of the MMP family matrix possess different substrate specificities, they all possess similar structural and functional features and demonstrate similar mechanisms of proteolysis. The catalytic of the MMPs is regulated at multiple levels including transcription, secretion, activation and inhibition. The growth and repair of connective tissues is a delicately balanced process of ECM removal and replacement with significant control by primary MMPs and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Dentists have a need to understand matrix turnover in the periodontal ligament and adjacent structures, embryology and development. How to cite this article Tandelilin RTC, Saini R. Dynamics of Matrix Metalloproteinases in the Oral Environment. Int J Experiment Dent Sci 2015;4(1):53-57.