Author:
Kheur Supriya M,Choudhari Sheetal S,Kulkarni Deepak G,Patankar Sangeeta
Abstract
ABSTRACT
Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. It also plays an important role in various pathologic conditions. Angiogenesis may contribute to the progression of fibrosis in fibrotic disorders. Inhibition of pathological angiogenesis is considered to be a new strategy for the treatment of various fibrotic disorders. In OSF, angiogenesis can be related to progression fibrosis. This article briefly describes the role of angiogenesis in pathogenesis of fibrosis in OSF and the importance of inhibition of pathologic angiogenesis in its prevention and treatment.
Clinical significance
Understanding the association between angiogenesis and fibrogenesis can help in developing new therapeutic strategies for treatment of OSF.
How to cite this article
Choudhari SS, Kulkarni DG, Patankar S, Kheur SM, Sarode SC, Sarode GS, Patil S. Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint. J Contemp Dent Pract 2018;19(2):242-245.
Publisher
Jaypee Brothers Medical Publishing
Cited by
5 articles.
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