Evaluation of Effects of Different Immunosuppressant Agents on Gingival Overgrowth

Abstract

ABSTRACT Background The purpose of this study is to evaluate the effects of different immunosuppressant agents on gingival overgrowth. Materials and methods About 60 patients medicated with cyclosporin A (CsA) and 40 patients with tacrolimus (TcR) were recruited in the study. Periodontal examination (PI, GI, PBI, PPD, GO) was carried out only for maxillary and mandibular anterior teeth. Pharmacologic variables, such as daily dosage of immunosuppressant agents, TcR/CsA whole blood level were recorded. Results In the group medicated with CsA, 10 patients had clinically significant GO, while none of the patients medicated with Tac had clinically significant GO. Significant differences were observed for periodontal parameters (PI, GI, PBI, PPD), post-transplant period, percentage of GO. In CsA group, significant difference was detected for periodontal parameters, percentage of GO and daily glucocorticoid dosage between responders and nonresponders. Conclusion The results from our study show that GO does not occur in patients medicated with TcR, although TcR shares same mechanism with CsA. How to cite this article Bekit A, Bagis N, Arpak N. Evaluation of Effects of Different Immunosuppressant Agents on Gingival Overgrowth. Int J Experiment Dent Sci 2015;4(1):17-22.