Efficacy of ProEx C in Detecting Cervical Squamous Epithelial Lesions: A Cross-sectional Study

Abstract

ABSTRACT Objectives To determine the diagnostic value of ProEx C in the detection of cervical squamous epithelial lesions. Materials and methods A cross-sectional study was conducted on 60 cataloged cervical biopsy specimens. The specimens were received from incident cases for routine histopathological evaluation in MS Ramaiah Hospital. Immunohistochemical examination was performed on paraffin biopsy blocks of the specimen for nuclear and cytosolic staining with ProEx C. From the data, the proportion of positive staining cells and the average intensity of staining were assessed. Results As per this study, the sensitivity and specificity of ProEx C were found to be 95 and 83%, respectively. Conclusion ProEx C is an ascertained highly sensitive and specific marker. This will help to overcome the drawbacks of basic screening methods in terms of inter- and intra-observer variations and false-positive and false-negative values, and either replace or complement the less economical human papillomavirus (HPV) DNA testing in the triage for developing nations. Clinical significance The use of ProEx C as an immunohistochemical marker is a highly reliable indicator of not only the presence of cervical squamous epithelial lesions but also the grade of the lesion. With high positive and negative predictive values for dysplasia and invasive carcinomas as well, ProEx C serves as an excellent diagnostic tool for cervical intraepithelial lesions. How to cite this article Nayak AU, Muthukumar V, Sridhar HS, et al. Efficacy of ProEx C in Detecting Cervical Squamous Epithelial Lesions: A Cross-sectional Study. J South Asian Feder Obst Gynae 2020;12(6):383–386.