Diagnostic and Management Challenges in Mikulicz Syndrome

Abstract

ABSTRACT Mikulicz disease (MD) is a disorder characterized by multiple lymphoepithelial lesions involving lacrimal and salivary glands. It is an uncommon condition, and very few cases are reported in the literature. It is a variant of Sjögren syndrome (SS) with patients presenting with clinical features over a wide range of spectrum. It is important to differentiate on which side of the disease spectrum the patient is presenting, i.e., either primary SS or secondary SS, because management can vary. The purpose of mentioning these two cases and its importance lie in the fact that the patients presented at two ends of the spectrum of SS – the first patient belonging to secondary SS and the second patient belonging to primary SS – which changes the line management for both patients, conservative and surgical respectively. The purpose of reporting these two cases is to emphasize the importance of identifying disease symptoms and signs early, which can help stratify the patient as a variant of primary SS or secondary SS and thus decide on the appropriate line of management, saving precious time and discomfort to the patient. Here we are mentioning two case reports of MD belonging to diagonally opposite spectrums of SS and their management with successful remission. How to cite this article Bhattacharjee A, Uddin S, Prakash R, Rathor A, Kalita S. Diagnostic and Management Challenges in Mikulicz Syndrome. Int J Head Neck Surg 2015;6(4): 139-145.