Comparison of Levels of Androgenic Hormones in various Phenotypes of Polycystic Ovarian Syndrome in High School Girls aging 14 to 18 Years

Abstract

ABSTRACT Introduction Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women. Polycystic ovarian syndrome is mainly diagnosed based on oligomenorrhea or amenorrhea accompanied by clinical or laboratory evidence of hyperandrogenemia. This study aimed to compare the levels of androgenic hormones in various phenotypes of PCOS in high school girls aged 14 to 18 years in 2009. Materials and methods This cross-sectional study was conducted on 3200 girl students aged 14 to 18 years. The research community included high school girls in different educational districts of Shiraz. After obtaining written informed consents, demographic questionnaire was completed and clinical signs of increased androgens (acne, hirsutism and alopecia) were recorded. In addition, ultrasound for cyst was performed for the students with menstrual disorders. Results The mean age of the study population was 16.17 ± 1.25 years. Hyperandrogenism and polycystic ovaries phenotype compared to other phenotypes were more prevalent (45 patients, 30.8%) in the study population. In addition, the mean testosterone, free testosterone (FT), and dehydroepiandrosterone sulfate (DHEAS) levels were higher in the patients with polycystic ovaries and hyperandrogenism. However, the results of independent t-test revealed no significant difference between the patients with polycystic ovaries and hyperandrogenism and noninfected participants regarding the mean hormone levels (p > 0.05). Yet, the correlation was significant in the other three phenotypes (p < 0.05). Moreover, 144 cases (4.6%) suffered from oligomenorrhea, 29.5% of whom presented PCOS symptoms in the ultrasound. Conclusion Androgenic hormone levels were higher in the PCOS phenotypes with menstrual disorders, particularly oligomenorrhea. Therefore, compared to other symptoms of hyperandrogenism and ultrasound, menstrual disorders were more important in PCOS. How to cite this article Akbarzadeh M, Naderi T, Dabbaghmaneh MH, Tabatabaee H. Comparison of Levels of Androgenic Hormones in various Phenotypes of Polycystic Ovarian Syndrome in High School Girls aging 14 to 18 Years. J South Asian Feder Obst Gynae 2016;8(1):33-39. The research is the result of the thesis proposal by Mrs Tahrei Naderi, No. 3958, is financially supported by the Research Vice-chancellor of Shiraz University of Medical Sciences.