Role Of Oxidative Stress And Antioxidant In Preeclampsia: A Study In Rural Population

Abstract

Pre-eclampsia is well known complication of gestation which generally occurs around 20 weeks of pregnancy; it is linked with large maternal and fetal mortality and morbidity. The disease comes with new-onset hypertension and proteinuria in the mother, which can further progress to dysfunction of multiple organs, and includes hepatic, renal and cerebral disease.To estimate malondialdehyde (MDA), glutathione reduced, superoxide dismutase and catalase in pregnant women with pre-eclampsia.Role of malondialdehyde, antioxidant and their relationship were estimated using different method. Preeclamptic group was compared with normal pregnant women and another group of pregnant women administered with supplementation of Vitamins. Very significant differences were seen, when compared with each group.In present study we found decrease in levels of reduced glutathione level in preeclamptic group as compared to normal and supplementation group. The levels of superoxide dismutase was found to be increased in present study in pre-eclamptic group as compared to normal pregnant women and pregnant women with supplementation and the differences were highly significant. In present study where antioxidants level was compared with preeclamptic group and group with supplementation the markedly significant variations were seen.Our finding on role of antioxidant in preeclampsia when compared with supplementation of Vitamins and normal pregnant women the result showed beneficial affect with the significant differences. It may provide new insight into a potentially modifiable way to prevent preeclampsia when these vitamins are administrated in diets.