The role of platelets in the pathogenesis of atherosclerosis

Author:

Nikolaeva T. O.1ORCID

Affiliation:

1. Tver State Medical University of Minzdrav of Russia

Abstract

The participation of platelets in the development of atherothrombosis in acute forms of cardiovascular diseases is generally recognized and well studied, while their significance in the pathogenesis of vascular atherosclerosis, starting from the earliest stages, requires further study. This article analyzes the role of platelets in the pathogenesis of atherosclerosis. Modern views on the pathogenesis of atherosclerosis, platelet-endothelial interactions, molecular mechanisms of platelet activation, platelet immune function from the point of view of the initial stages of atherogenesis, studies of the effect of antiplatelet therapy in primary and secondary prevention of atherosclerosis are considered. The leading role of platelets in the inflammatory and immune reactions of the human body is indicated, which is realized due to a complex of immune receptors, adhesion molecules and mediators.

Publisher

The Institute of Internal and Preventive Medicine

Reference106 articles.

1. Zdravookhranenie v Rossii. 2019: Stat. sb. / Rosstat. M.: Z-46, 2019. S. 170. (In Russ.).

2. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiiskoi Federatsii v 2019 godu: Gosudarstvennyi doklad. M.: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka, 2020. S. 299. (In Russ.).

3. Kuharchuk V.V., Ezhov M.V., Sergienko I.V., Arabidze G.G., Bubnova M.G., Balahonova T.V., Gurevich V.S., Kachkovskij M.A., Konovalov G.A., Konstantinov V.O., Malyshev P.P., Pokrovskij S.D., Sokolov A.A., Sumarokov A.B., Gornyakova D.B., Obrezan A.G., Shaposhnik I.I., Anciferov M.B., Ansheles A.A., Aronov D.M., Ahmedzhanov N.M., Barbarash O.L., Bojcov S.A., Voevoda M.I., Galstyan G.R., Galyavich A.S., Drapkina O.M., Duplyakov D.V., Eryogin S.Ya., Karpov R.S., Karpov Yu.A., Koziolova N.A., Kosmachyov E.D., Nebieridze D.V., Nedogoda S.V., Olejnikov V.E., Ragino Yu.I., Skibickij V.V., Smolenskaya O.G., Filippov A.E., Halimov Yu.Sh., Chazova I.E., Shestakova M.V., Yakushin S.S. Diagnostika i korrekciya narushenij lipidnogo obmena s cel’yu profilaktiki i lecheniya ateroskleroza. Rossijskie rekomendacii, VII peresmotr. Ateroskleroz i dislipidemii, 2020; 1. URL: https://cyberleninka.ru/article/n/diagnostika-i-korrektsiyanarusheniy-lipidnogo-obmena-s-tselyu-profilaktiki-ilecheniya-ateroskleroza-rossiyskie-rekomendatsii-vii (data obrashcheniya: 24.06.2021). (In Russ.)

4. European guidelines on cardiovascular disease prevention in clinical practice: the sixth joint task force of the European society of cardiology and other Societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European association for cardiovascular prevention & rehabilitation (EACPR). Atherosclerosis, 2016; 2016: 207–274.

5. Vasil’ev S.A., Melkumyan A.L., Berkovskij A.L., Suvorov A.V., Mazurov A.V., Kozlov A.A. Kliniko-laboratornaya diagnostika narushenij funkcij trombocitov. Metodicheskoe rukovodstvo. Moskva, 2013, 76 p. ISBN: 978-5-906548-07-8. (In Russ.)

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