Synthesis, Characterization and Biochemical Activity of Homo and Heterobimetallic Derivatives of Dibutyltin Containing Mixed Chelating Ligands

Abstract

Bu2Sn(OPri)2's interaction with Schiff base (LaH), where La = L1 = OC6H4CH=NCNSC6H4 (1) and La = L2 = O2NC6H4CH=NCH2CH2O (2) yields the precursor derivatives Bu2Sn(La)(OPri), which on equimolar reaction with glycol (HOGOH), where G = G1 = OCH(Me)CH(Me)O, and G = G2 = OC(Me)2C(Me)2O, and diethanolamine RN(CH2CH2OH)2 yield the derivative of the type Bu2Sn(La)(LbH) [where La = L1, Lb = G1 (3); La = L1, Lb = G2 (4); La = L2, Lb = G1 (5); La = L2, Lb = G2 (6); La = L1, Lb = RN(CH2CH2O)2 where R=H(7); La = L1, Lb = RN(CH2CH2O)2 where R=CH3(8); La = L2, Lb = RN(CH2CH2O)2 where R=H(9); La = L2, Lb = RN(CH2CH2O)2 where R= CH3(10)]. Homometallic mixed ligand derivatives (3)-(10) on 1:1 reaction with aluminium isopropoxide form monomeric heterobimetallic mixed chelating ligand derivatives of type [Bu2Sn(La)(LbAl(OPri)2] (11)-(18) respectively. All these derivatives have been characterized by elemental analysis and spectroscopic [IR, NMR 1H, 119Sn, and 27Al ] studies. The synthesized derivatives were screened for their in vitro antimicrobial activity against gram +ve bacteria i.e.S.aureus and gram -ve bacteria i.e. E.Coli. All the derivatives showed enhanced antimicrobial activity than the present ligands.