Abstract
Introduction. The work is devoted to problem of gastrointestinal tract functioning due to chronic problem in kidneys. The initial recognition of kidney disease as independent from other medical conditions is widely attributed to Richard Bright’s 1827 book “Reports of Medical Cases,” which detailed the features and consequences of kidney disease. The CKD influence GIT by Disruption of the colonic microbiome and its attendant as a result of which there is loss of gut barrier integrity and increased generation of uremic toxins resulting in disruption of GIT normal functioning.
Goal. To study the causes of clinical manifestations of chronic kidney disease and how it affects GIT.
Materials and Methods. Review of modern and foreign literary sources; methods – description, analysis, abstracting.
Results and discussion. CKD is common in US and in adults over 30 the reason behind that is Diabetes leading to kidney disease. Both: type 1 and type 2 diabetes. But also heart disease and obesity can contribute to the damage that causes kidneys to fail. Research suggests that gene GPX1, GSTO1, GSTO2, UMOD, and MGP genes are associated with CKD. The pathophysiology of CKD has a lot to contribute in GIT malfunctioning.
Conclusions. The link between GIT malfunctioning and kidney pathology can be explained by the pathophysiology of CKD and its outcomes affecting GIT.
Publisher
Publishing house Uston Ltd
Subject
Industrial and Manufacturing Engineering,Polymers and Plastics,Business and International Management
Reference10 articles.
1. Schepens D, Verswijvel G, Kuypers D, Vanrenterghem Y. Renal cortical nephrocalcinosis. Nephrology Dialysis Transplantation. 2000; 15(7): pp. 1080–1082. doi: 10.1093/ndt/15.7.1080
2. CDC. Chronic Kidney Disease in the United States, 2019. https://www.cdc.gov/kidneydisease/publications-resources/2019-nationalfacts. html#calculation. Accessed September 2, 2020.
3. Friedman DJ, Pollak MR. APOL1 Nephropathy: From Genetics to Clinical Applications. Clinical Journal of the American Society of Nephrology. 2020; 16(2): pp. 294–303. doi: 10.2215/cjn.15161219.
4. National Kidney Foundation. How to Classify CKD. https://www.kidney.org/professionals/explore-your-knowledge/how-to-classify-ckd. Accessed September 3, 2020.
5. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. https://kdigo.org/wp-content/uploads/2017/02/KDIGO_2012_CKD_GL.pdf. Updated January 1, 2013. Accessed July 18, 2021.