ASSESSMENT OF CLINICAL FEATURES AND TREATMENT OPTIMIZATION OF ACUTE VARICELLA-ZOSTER VIRUS MYOCARDITIS: AN OBSERVATIONAL STUDY

Abstract

The purpose of the study: to explore the frequency of development, features of the clinical course and treatment of acute myocarditis in adults with chickenpox. Materials and methods. This study included 240 patients with chickenpox between the ages of 18 and 40 years. Clinical, biochemical, molecular genetics and instrumental examination methods were used for assessment. Examination of selected patients was carried out in the acute period, after normalization of body temperature and before being discharged from the hospital. Student’s t test was used for statistical evaluation. Results and discussion. Acute myocarditis was diagnosed in 16.6% of patients with chickenpox caused by Varicella-zoster virus. A high correlation has been revealed between the severity of chickenpox and the frequency of development, as well as the severity of acute myocarditis in adults. Conclusions. An increase in CRP, sialic acid and fibrinogen in the blood serum of chickenpox patients reflects the severity of the disease, but is not specific for myocarditis. Treatment of acute myocarditis in patients with chickenpox should be early and comprehensive.