Recapitulation of Skewed X-Inactivation in Female Ornithine Transcarbamylase-Deficient Primary Human Hepatocytes in the FRG Mouse: A Novel System for Developing Epigenetic Therapies

Author:

Cunningham Sharon C.1ORCID,van Dijk Eva B.1,Zhu Erhua1,Sugden Maya1,Mandwie Mawj1,Siew Susan23,Devanapalli Beena4,Tolun Adviye Ayper34,Klein Anne5,Wilson Laurence56,Aryamanesh Nader7,Gissen Paul8,Baruteau Julien8,Bhattacharya Kaustuv39,Alexander Ian E.13

Affiliation:

1. Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

2. Department of Gastroenterology, James Fairfax Institute of Paediatric Nutrition, Sydney Children's Hospitals Network, Westmead, Australia.

3. Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.

4. NSW Biochemical Genetics Service, The Children's Hospital at Westmead, Westmead, Australia.

5. Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Sydney, Australia.

6. Department of Biomedical Sciences, Macquarie University, Macquarie Park, Australia.

7. Embryology Research Unit, Bioinformatics Group, Children's Medical Research Institute, University of Sydney, Westmead, Australia.

8. National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London, United Kingdom.

9. Genetic Metabolic Disorders Service, The Children's Hospital at Westmead, Sydney, Australia.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Gene therapy clinical trials worldwide to 2023—an update;The Journal of Gene Medicine;2024-08

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