Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler

Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler–Najjar Syndrome

Published:2019-10-01 Issue:10 Volume:30 Page:1297-1305
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Aronson Sem J.¹,Veron Philippe²,Collaud Fanny²,Hubert Aurélie³,Delahais Virginie²,Honnet Géraldine²,de Knegt Robert J.⁴,Junge Norman⁵⁶,Baumann Ulrich⁵⁶,Di Giorgio Angelo⁷,D'Antiga Lorenzo⁷,Ginocchio Virginia M.⁸⁹,Brunetti-Pierri Nicola⁸⁹,Labrune Philippe³,Beuers Ulrich¹,Bosma Piter J.¹,Mingozzi Federico²

Affiliation:

1. Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

2. Genethon, Evry, France

3. Department of Hereditary Diseases of Hepatic Metabolism, Hôpital Antoine Béclère, Clamart, France

4. Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands

5. Department of Paediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany

6. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

7. Department of Paediatric Hepatology, Gastroenterology and Transplantation, Papa Giovanni XXIII Hospital, Bergamo, Italy

8. Telethon Institute of Genetics & Medicine (TIGEM), Pozzuoli, Italy

9. Department of Translational Medicine, Federico II University of Naples, Naples, Italy.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/hum.2019.143

Reference45 articles.

1. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

2. Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

3. Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease

4. Phototherapy for Neonatal Jaundice

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