Lung Deposition of Alpha1-Proteinase Inhibitor (Human) (A1-PI[H]) Inhalation Solution Using Two Inhalation Modes of the I-neb Adaptive Aerosol Delivery (AAD) System in Healthy Subjects and Subjects with Cystic Fibrosis-Reference-Cited by-同舟云学术

Lung Deposition of Alpha1-Proteinase Inhibitor (Human) (A1-PI[H]) Inhalation Solution Using Two Inhalation Modes of the I-neb Adaptive Aerosol Delivery (AAD) System in Healthy Subjects and Subjects with Cystic Fibrosis

Published:2016-06 Issue:3 Volume:29 Page:242-250
ISSN:1941-2711
Container-title:Journal of Aerosol Medicine and Pulmonary Drug Delivery
language:en
Short-container-title:Journal of Aerosol Medicine and Pulmonary Drug Delivery

Author:

Häussermann Sabine¹,Winnips Cornelis²,Edelman Jonathan³,Kappeler Dominik¹,Herpich Christiane¹,Ehlich Hilke¹,Zanker Daniela¹,Kietzig Claudius¹,Sommerer Knut¹

Affiliation:

1. Inamed GmbH, Gauting, Germany.

2. CSL Behring AG, Bern, Switzerland.

3. CSL Behring LLC, King of Prussia, Pennsylvania.

Publisher

Mary Ann Liebert Inc

Subject

Pharmacology (medical),Pharmaceutical Science,Pulmonary and Respiratory Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/jamp.2014.1173

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2. Mucoid Pseudomonas aeruginosa

3. Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.

4. The intrapulmonary half-life and safety of aerosolized alpha1-protease inhibitor in normal volunteers.

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