Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics-Reference-Cited by-同舟云学术

Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics

Published:2016-08 Issue:4 Volume:26 Page:210-215
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Henry Scott P.¹,Seguin Rosanne²,Cavagnaro Joy³,Berman Cindy⁴,Tepper Jeff⁵,Kornbrust Douglas⁶

Affiliation:

1. Preclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California.

2. Clinical Research Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.

3. Access BIO, Boyce, Virginia.

4. Berman Consulting, Wayland, Virginia.

5. Tepper Nonclinical Consulting, San Carlos, California.

6. Preclinsight, Reno, Nevada.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2015.0593

Reference20 articles.

1. Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey

2. Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics

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