Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2′-O-Methoxyethyl Modified Antisense Oligonucleotide
Author:
Affiliation:
1. Ionis Pharmaceuticals, Inc., Carlsbad, California.
2. SNBL, USA, Ltd., Everett, Washington.
3. National Jewish Health, Denver, Colorado.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
http://www.liebertpub.com/doi/pdf/10.1089/nat.2015.0584
Reference37 articles.
1. Antisense Drug Technology
2. Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics
3. Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans
4. Mechanism of Alternative Complement Pathway Dysregulation by a Phosphorothioate Oligonucleotide in Monkey and Human Serum
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