Humanization of Predicted T-Cell Epitopes Reduces the Immunogenicity of Chimeric Antibodies: New Evidence Supporting a Simple Method
Author:
Affiliation:
1. Research and Development Department, Center of Molecular Immunology, Havana, Cuba.
2. Department of Microbiology and Molecular Genetics, UCLA, Los Angeles, California.
Publisher
Mary Ann Liebert Inc
Subject
Genetics,Immunology
Link
http://www.liebertpub.com/doi/pdf/10.1089/153685903322328974
Reference43 articles.
1. Continuous cultures of fused cells secreting antibody of predefined specificity
2. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.
3. Conformations of immunoglobulin hypervariable regions
4. Antibody framework residues affecting the conformation of the hypervariable loops
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