Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9

Author:

Weihs Antoine1,Chaker Layal23,Martin Tiphaine C.45,Braun Kim V.E.6,Campbell Purdey J.7,Cox Simon R.8,Fornage Myriam910,Gieger Christian111213,Grabe Hans J.114,Grallert Harald1112,Harris Sarah E.8,Kühnel Brigitte1112,Marioni Riccardo E.15,Martin Nicholas G.16,McCartney Daniel L.15,McRae Allan F.17,Meisinger Christa18,van Meurs Joyce B.J.1920,Nano Jana1221,Nauck Matthias2223,Peters Annette11121321,Prokisch Holger2425,Roden Michael262728,Selvin Elizabeth2930,Beekman Marian31,van Heemst Diana32,Slagboom Eline P.31,Swenson Brenton R.33ORCID,Tin Adrienne2934,Tsai Pei-Chien53536,Uitterlinden Andre19,Visser W. Edward2,Völzke Henry2337,Waldenberger Melanie111213,Walsh John P.738,Köttgen Anna2939,Wilson Scott G.5740,Peeters Robin P.2,Bell Jordana T.5,Medici Marco2,Teumer Alexander1233741ORCID

Affiliation:

1. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.

2. Erasmus MC Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

3. Erasmus MC Academic Center for Thyroid Diseases, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

4. Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

5. Department of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, London, United Kingdom.

6. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

7. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.

8. Lothian Birth Cohorts, Department of Psychology; Institute of Genetics and Cancer; University of Edinburgh, Edinburgh, United Kingdom.

9. Brown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, Texas, USA.

10. Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

11. Research Unit Molecular Epidemiology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.

12. Institute of Epidemiology, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.

13. German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.

14. German Centre for Neurodegenerative Diseases (DZNE), Site Rostock, Greifswald, Germany.

15. Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer; University of Edinburgh, Edinburgh, United Kingdom.

16. QIMR Berghofer Medical Research Institute, Brisbane, Australia.

17. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.

18. Epidemiology, Medical Faculty, University of Augsburg, Augsburg, Germany.

19. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

20. Department of Orthopeadics and Sports Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

21. Institute for Medical Informatics, Biometrics and Epidemiology, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.

22. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

23. DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

24. Institute of Neurogenomics, Computational Health Center; Helmholtz Munich, Neuherberg, Germany.

25. Institute of Human Genetics, School of Medicine, Technical University Munich, Munich, Germany.

26. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Medical Faculty; Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

27. Division of Endocrinology and Diabetology, Medical Faculty; Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

28. German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

29. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

30. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

31. Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.

32. Section of Gerontology and Geriatrics, Department of Internal Medicine; Leiden University Medical Center, Leiden, Netherlands.

33. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.

34. Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

35. Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.

36. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.

37. Institute for Community Medicine; University Medicine Greifswald, Greifswald, Germany.

38. Medical School, University of Western Australia, Crawley, Australia.

39. Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg, Freiburg, Germany.

40. School of Biomedical Sciences, University of Western Australia, Perth, Australia.

41. Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.

Publisher

Mary Ann Liebert Inc

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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