Asn25 Deamidation as an Allosteric Tool to Increase IFNβ-1a Biological Activity-Reference-Cited by-同舟云学术

Asn25 Deamidation as an Allosteric Tool to Increase IFNβ-1a Biological Activity

Published:2022-06-01 Issue:6 Volume:42 Page:251-266
ISSN:1079-9907
Container-title:Journal of Interferon & Cytokine Research
language:en
Short-container-title:Journal of Interferon & Cytokine Research

Author:

Lipari Elisa¹,Saporiti Simona²^ORCID,Eberini Ivano²³,Massimo Luigia¹⁴,Mazzarella Enrico¹⁵,Anderloni Giulia¹⁵,Rossi Mara⁶,D'Amici Fabio¹,Pergola Carlo¹,Palinsky Wolf⁷,D'Acunto Cosimo Walter¹,Centola Fabio⁶

Affiliation:

1. Analytical Development Biotech, Merck Serono S.p.A., Rome, Italy (an Affiliate of Merck KGaA, Darmstadt, Germany).

2. Dipartimento di Scienze Farmacologiche e Biomolecolari and Università degli Studi di Milano, Milano, Italy.

3. Data Science Research Center (DSRC), Università degli Studi di Milano, Milano, Italy.

4. Dipartimento di Farmacia, Università degli Studi di Salerno, Fisciano, Italy.

5. Sezione di Medicina Interna e Malattie Metaboliche, Dipartimento di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.

6. Global Analytical Pharmaceutical Science and Innovation, Merck Serono S.p.A., Rome, Italy (an Affiliate of Merck KGaA, Darmstadt, Germany).

7. Biotech Development Programme, Merck Biopharma, Aubonne, Switzerland (an Affiliate of Merck KGaA, Darmstadt, Germany).

Publisher

Mary Ann Liebert Inc

Subject

Virology,Cell Biology,Immunology

Link

https://www.liebertpub.com/doi/pdf/10.1089/jir.2021.0209

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1. Intrinsic Activity

2. Fast optimal leaf ordering for hierarchical clustering

3. Monte Carlo studies of the dielectric properties of water-like models

4. Identification and Characterization of Deamidation Sites in the Conserved Regions of Human Immunoglobulin Gamma Antibodies