Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay
Author:
Affiliation:
1. Cornell/Rockefeller/Sloan-Kettering Tri-Institutional Program in Computational Biology and Medicine, New York, New York.
2. Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/adt.2009.0250
Reference43 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2. The influence of drug-like concepts on decision-making in medicinal chemistry
3. The influence of lead discovery strategies on the properties of drug candidates
4. Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
Cited by 56 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain;Neurobiology of Pain;2023-08
2. Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function;Journal of General Physiology;2023-02-10
3. Anionic lipids unlock the gates of select ion channels in the pacemaker family;Nature Structural & Molecular Biology;2022-11
4. Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature;Frontiers in Physiology;2022-03-08
5. Mechanisms underlying drug-mediated regulation of membrane protein function;Proceedings of the National Academy of Sciences;2021-11-09
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3