Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity-Reference-Cited by-同舟云学术

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

Published:2013-11-10 Issue:14 Volume:19 Page:1619-1633
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Lipiski Miriam¹,Deuel Jeremy W.¹,Baek Jin Hyen²,Engelsberger Wolfgang R.¹,Buehler Paul W.²,Schaer Dominik J.¹

Affiliation:

1. Division of Internal Medicine, University of Zurich, Zurich, Switzerland.

2. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/ars.2012.5089

Reference43 articles.

1. Structure of the haptoglobin–haemoglobin complex

2. Haptoglobin Genotype– and Diabetes-Dependent Differences in Iron-Mediated Oxidative Stress In Vitro and In Vivo

3. Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular Disease

4. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

5. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

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