Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis

Author:

Osinga Joris A.J.12ORCID,Liu Yindi12,Männistö Tuija3,Vafeiadi Marina4,Tao Fang-Biao5,Vaidya Bijay6,Vrijkotte Tanja G.M.7,Mosso Lorena8,Bassols Judit9,López-Bermejo Abel1011,Boucai Laura12ORCID,Aminorroaya Ashraf13,Feldt-Rasmussen Ulla14ORCID,Hisada Aya15,Yoshinaga Jun16,Broeren Maarten A.C.17,Itoh Sachiko18,Kishi Reiko18,Ashoor Ghalia19,Chen Liangmiao20,Veltri Flora21,Lu Xuemian20,Taylor Peter N.22,Brown Suzanne J.23,Chatzi Leda24,Popova Polina V.25,Grineva Elena N.26,Ghafoor Farkhanda27,Pirzada Amna28,Kianpour Maryam13,Oken Emily29,Suvanto Eila30,Hattersley Andrew31,Rebagliato Marisa323334,Riaño-Galán Isolina34353637,Irizar Amaia343839,Vrijheid Martine344041,Delgado-Saborit Juana Maria3242,Fernández-Somoano Ana343536,Santa-Marina Loreto343843,Boelaert Kristien44,Brenta Gabriela45ORCID,Dhillon-Smith Rima46,Dosiou Chrysoula47,Eaton Jennifer L.48,Guan Haixia49ORCID,Lee Sun Y.50ORCID,Maraka Spyridoula515253,Morris-Wiseman Lilah F.54,Nguyen Caroline T.55,Shan Zhongyan56,Guxens Mònica34404157,Pop Victor J.M.58,Walsh John P.2359ORCID,Nicolaides Kypros H.60,D'Alton Mary E.61,Visser W. Edward12,Carty David M.6263,Delles Christian63,Nelson Scott M.64ORCID,Alexander Erik K.65,Chaker Layal126667,Palomaki Glenn E.68,Peeters Robin P.12,Bliddal Sofie14ORCID,Huang Kun69,Poppe Kris G.21,Pearce Elizabeth N.50ORCID,Derakhshan Arash12,Korevaar Tim I.M.12

Affiliation:

1. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

2. Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.

3. Northern Finland Laboratory Center Nordlab and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

4. Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.

5. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China.

6. Department of Endocrinology, Royal Devon and Exeter Hospital NHS Foundation Trust, University of Exeter Medical School, Exeter, United Kingdom.

7. Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

8. Departments of Endocrinology, Pontificia Universidad Catolica de Chile, Santiago, Chile.

9. Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta Hospital, Girona, Spain.

10. Pediatric Endocrinology Research Group, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta Hospital, Girona, Spain.

11. Departament de Ciències Mèdiques, Universitat de Girona, Girona, Spain.

12. Division of Endocrinology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell University, New York, New York, USA.

13. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

14. Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark.

15. Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

16. Faculty of Life Sciences, Toyo University, Gunma, Japan.

17. Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, The Netherlands.

18. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.

19. Harris Birthright Research Center for Fetal Medicine, King's College Hospital, London, United Kingdom.

20. Department of Endocrinology and Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

21. Endocrine Unit, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

22. Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom.

23. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

24. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

25. Institute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia.

26. Department of Endocrinology, First Medical University, Saint Petersburg, Russia.

27. Department of Research and Innovation, Shalamar Institute of Health Sciences, Lahore, Pakistan.

28. Shifa College of Medicine, Islamabad, Pakistan.

29. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

30. Department of Obstetrics and Gynecology and Medical Research Center Oulu, University of Oulu, Oulu, Finland.

31. Department of Molecular Medicine, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, Devon, United Kingdom.

32. Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain.

33. Predepartamental Unit of Medicine, Jaume I University, Castelló, Spain.

34. Spanish Consortium for Research on Epidemiology and Public Health, Instituto de Salud Carlos III, Madrid, Spain.

35. Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Asturias, Spain.

36. IUOPA–Department of Medicine, University of Oviedo, Oviedo, Asturias, Spain.

37. Servicio de Pediatría, Endocrinología Pediátrica, HUCA, Oviedo, Asturias, Spain.

38. Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, San Sebastian, Spain.

39. Department of Preventive Medicine and Public Health, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.

40. ISGlobal, Barcelona, Spain.

41. Universitat Pompeu Fabra, Barcelona, Spain.

42. Department of Medicine, Faculty of Health Sciences, Universitat Jaume I, Castellón de la Plana, Spain.

43. Department of Health of the Basque Government, Subdirectorate of Public Health of Gipuzkoa, San Sebastian, Spain.

44. Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

45. Department of Internal Medicine, Unidad Asistencial Dr. César Milstein, Buenos Aires, Argentina.

46. Tommys National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

47. Division of Endocrinology, Stanford University School of Medicine, Stanford, California, USA.

48. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and Women and Infants Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

49. The First Hospital of China Medical University, Shenyang, China.

50. Section of Endocrinology, Diabetes, and Nutrition, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.

51. Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

52. Knowledge and Evaluation Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

53. Endocrine Section, Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

54. Division of Endocrine Surgery, Johns Hopkins Department of Surgery, Baltimore, Maryland, USA.

55. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

56. Department of Endocrinology and Metabolism, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

57. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.

58. Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.

59. Medical School, University of Western Australia, Crawley, Western Australia, Australia.

60. Department of Women and Children's Health, Faculty of Life Sciences and Medicine King's College London, London, United Kingdom.

61. Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.

62. Department of Diabetes, Endocrinology and Clinical Pharmacology, Glasgow Royal Infirmary, Glasgow, United Kingdom.

63. School of Cardiovascular and Metabolic Health, Dentistry and Nursing, University of Glasgow, Glasgow, United Kingdom.

64. School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, United Kingdom.

65. Division of Endocrinology, Hypertension and Diabetes, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

66. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

67. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

68. Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

69. Department of Maternal, Child and Adolescent Health, Scientific Research Center in Preventive Medicine; School of Public Health; Anhui Medical University, Hefei, Anhui, China.

Publisher

Mary Ann Liebert Inc

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