Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy

Author:

Kochanek Patrick M.1,Bramlett Helen M.2,Dixon C. Edward3,Shear Deborah A.4,Dietrich W. Dalton5,Schmid Kara E.6,Mondello Stefania7,Wang Kevin K.W.8,Hayes Ronald L.9,Povlishock John T.10,Tortella Frank C.11

Affiliation:

1. Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

2. Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, and Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, Florida.

3. Department of Neurological Surgery, Brain Trauma Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

4. In Vivo Neuroprotection Labs, Brain Trauma Neuroprotection & Neurorestoration Branch, Center of Excellence for Psychiatry & Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland.

5. Miami Project to Cure Paralysis, Departments of Neurological Surgery, Neurology and Cell Biology, Miller School of Medicine, University of Miami, Miami, Florida.

6. Brain Trauma Neuroprotection and Neurorestoration Department, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland.

7. Department of Neurosciences, University of Messina, Messina, Italy.

8. Center of Neuroproteomics and Biomarkers Research, Department of Psychiatry and Neuroscience, University of Florida, Gainesville, Florida.

9. Center for Innovative Research, Center for Neuroproteomics and Biomarkers Research, Banyan Biomarkers, Inc., Alachua, Florida.

10. Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia.

11. Department of Applied Neurobiology and Combat Casualty Care Research Program for Brain Trauma & Neuroprotection Research, Walter Reed Army Institute of Research, Silver Spring, Maryland.

Publisher

Mary Ann Liebert Inc

Subject

Neurology (clinical)

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