Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering-Reference-Cited by-同舟云学术

Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering

Published:2019-06 Issue:3 Volume:30 Page:102-120
ISSN:1946-6536
Container-title:Human Gene Therapy Methods
language:en
Short-container-title:Human Gene Therapy Methods

Author:

Oberschmidt Olaf¹,Morgan Michael²³,Huppert Volker⁴,Kessler Joerg⁵,Gardlowski Tanja⁶,Matthies Nadine¹,Aleksandrova Krasimira⁷,Arseniev Lubomir⁷,Schambach Axel²³⁸,Koehl Ulrike¹⁶⁹,Kloess Stephan¹⁶

Affiliation:

1. Institute for Cellular Therapeutics, ATMP-GMP Development Unit, Hannover Medical School, Hannover, Germany;

2. Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany;

3. REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany;

4. Glycostem, Oss, the Netherlands;

5. Miltenyi Biotec GmbH, Bergisch-Gladbach, Germany;

6. Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany;

7. Institute for Cellular Therapeutics, Cellular Therapy Centre, Hannover Medical School, Hannover, Germany;

8. Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts;

9. Institute of Clinical Immunology, Universitätsklinikum Leipzig, Leipzig, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Genetics (clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/hgtb.2019.039

Reference55 articles.

1. Activation of NK cell cytotoxicity

2. Up on the tightrope: natural killer cell activation and inhibition

3. Signatures of Human NK Cell Development and Terminal Differentiation

4. Human NK cells: From surface receptors to clinical applications

5. Innate or Adaptive Immunity? The Example of Natural Killer Cells

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