Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types
Author:
Affiliation:
1. Tocagen, Inc., San Diego, California.
Publisher
Mary Ann Liebert Inc
Subject
Genetics (clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2015.106
Reference59 articles.
1. A Uniquely Stable Replication-Competent Retrovirus Vector Achieves Efficient Gene Deliveryin Vitroand in Solid Tumors
2. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
3. Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model
4. Highly Efficient and Tumor-Restricted Gene Transfer to Malignant Gliomas by Replication-Competent Retroviral Vectors
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