Sustained Inhibition of HIV-1 Replication by Conditional Expression of theE. coli-Derived Endoribonuclease MazF in CD4+T cells
Author:
Affiliation:
1. Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
2. Center for Cell and Gene Therapy, Takara Bio Inc., Otsu 520-2193, Japan.
Publisher
Mary Ann Liebert Inc
Subject
Genetics (clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2012.131
Reference28 articles.
1. Establishment of a CCR5-Expressing T-Lymphoblastoid Cell Line Highly Susceptible to R5 HIV Type 1
2. Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652
3. Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-SpecificE. colimRNA Interferase
4. In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model
5. Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
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