Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo-Reference-Cited by-同舟云学术

Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo

Published:2015-12 Issue:6 Volume:26 Page:211-220
ISSN:1946-6536
Container-title:Human Gene Therapy Methods
language:en
Short-container-title:Human Gene Therapy Methods

Author:

Li Baozheng¹,Ma Wenqin¹,Ling Chen¹²³,Van Vliet Kim⁴,Huang Lin-Ya⁴,Agbandje-McKenna Mavis²³⁴,Srivastava Arun¹²³⁵⁶,Aslanidi George V.¹²³

Affiliation:

1. Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida.

2. Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, Florida.

3. Genetics Institute, University of Florida College of Medicine, Gainesville, Florida.

4. Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida.

5. Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida.

6. Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida.

Publisher

Mary Ann Liebert Inc

Subject

Genetics (clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2015.115

Reference39 articles.

1. The cryptic life style of adenoassociated virus

2. Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

3. Immune responses to AAV vectors: overcoming barriers to successful gene therapy

4. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

5. CD8+ T-cell responses to adeno-associated virus capsid in humans

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Emerging trends in virus and virus-like particle gene therapy delivery to the brain;Molecular Therapy - Nucleic Acids;2024-09

2. Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy;Molecular Therapy - Nucleic Acids;2023-06

3. Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism;Scientific Reports;2023-05-25

4. Strategies to improve safety profile of AAV vectors;Frontiers in Molecular Medicine;2022-11-01

5. Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution;Translational Vision Science & Technology;2022-08-26