Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May Confound In Vivo Gene Therapy Studies-Reference-Cited by-同舟云学术

Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May Confound In Vivo Gene Therapy Studies

Published:2015-06 Issue:3 Volume:26 Page:103-105
ISSN:1946-6536
Container-title:Human Gene Therapy Methods
language:en
Short-container-title:Human Gene Therapy Methods

Author:

Calcedo Roberto¹,Franco Judith¹,Qin Qiuyue¹,Richardson Dean W.²,Mason Jeffery B.²,Boyd Surina¹,Wilson James M.¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, School of Medicine and Department of Clinical Studies, University of Pennsylvania, Philadelphia, PA 19104.

2. New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Publisher

Mary Ann Liebert Inc

Subject

Genetics(clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2015.082

Reference14 articles.

1. Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

2. Preexisting Immunity and Low Expression in Primates Highlight Translational Challenges for Liver-directed AAV8-mediated Gene Therapy

3. Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

4. Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

5. Evaluation of Gene Therapy as a Treatment for Equine Traumatic Arthritis and Osteoarthritis

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