Improved Minicircle DNA Biosynthesis for Gene Therapy Applications
Author:
Affiliation:
1. Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Covilhã 6200-506, Portugal.
2. Centre de Biophysique Moléculaire CNRS UPR4301, INSERM, and University of Orléans, F-45071 Orléans Cedex 2, France.
Publisher
Mary Ann Liebert Inc
Subject
Genetics (clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2013.020
Reference31 articles.
1. Plasmid DNA production for pharmaceutical use: Role of specific growth rate and impact on process design
2. Inducible Escherichia coli fermentation for increased plasmid DNA production
3. Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression
4. Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery
5. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
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