Update February 2023-Reference-Cited by-同舟云学术

Update February 2023

Published:2023-02-01 Issue:1 Volume:21 Page:78-96
ISSN:1539-6851
Container-title:Lymphatic Research and Biology
language:en
Short-container-title:Lymphatic Research and Biology

Author:

Blei Francine¹

Affiliation:

1. Hassenfeld Children's Hospital at NYU Langone, NYU Grossman School of Medicine, New York, New York, USA.

Publisher

Mary Ann Liebert Inc

Subject

Cardiology and Cardiovascular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/lrb.2023.29136.fb

Reference69 articles.

1. Update February 2023 Francine Blei, MD

2. TGF-β signaling in lymphatic vascular vessel formation and maintenance

3. Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

4. LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

5. Han, D., et al. (2023). ``Lymphatic uptake of biotherapeutics through a 3D hybrid discrete-continuum vessel network in the skin tissue.'' J Control Release: 11942. E-Pub 01/09/2023 Subcutaneous administration is a common approach for the delivery of biotherapeutics, which is achieved mainly through the absorption across Iymphatic vessels. In this paper, the drug transport and Iymphatic uptake through a three-dimensional hybrid discrete-continuum vessel network in the skin tissue are investigated through high-fidelity numerical simulations. We find that the local Iymphatic uptake through the explicit vessels significantly affects macroscopic drug absorption. The diffusion of drug solute through the explicit vessel network affects the Iymphatic uptake after the injection. This effect, however, cannot be captured using previously developed continuum models. The lymphatic uptake is dominated by the convection due to lymphatic drainage driven by the pressure difference, which is rarely studied in experiments and simulations. Furthermore, the effects of injection volume and depth on the Iymphatic uptake are investigated in a multilayered domain. We find that the injection volume significantly affects the rate of Iymphatic uptake through the heterogeneous vessel network, while the injection depth has little influence, which is consistent with the experimental results. At last, the binding and metabolism of drug molecules are studied to bridge the simulation to the experimentally measured drug clearance. We provide a new approach to study the diffusion and convection of drug molecules into the Iymphatic system through the hybrid vessel network.

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